Rob Morrow stars as FBI agent Don Eppes, who recruits his mathematical genius brother, Charlie (David Krumholtz), to help the Bureau solve a wide range of challenging crimes in Los Angeles. From two very different perspectives, the brothers take on the most confounding criminal cases, aided by Don‘s partner, Terry Lake (Sabrina Lloyd), and new FBI recruit David Sinclair (Alimi Ballard). Although their father, Alan (Judd Hirsch), is pleased to see his sons working together, he fears their competitive nature will lead to trouble. Charlie‘s colleague, physicist Dr. Larry Fleinhardt (Peter MacNicol), urges Charlie to focus more on his university studies than on FBI business. Inspired by actual events, NUMB3RS depicts how the confluence of police work and mathematics provides unexpected revelations and answers to the most perplexing criminal questions.

Rob Morrow扮演的FBI探员和他那具备超乎常人数学天才的弟弟Charlie一起侦破了在L.A发生的大范围严重罪案。Charlie对案件独特的思考方式让Don的同僚Terry Lake 和David Sinclair 都感到十分惊讶。与此同时，Don和Charlie的父亲对于两个儿子专注执着的个性会否使彼此在工作中产生摩擦感到担心。Larry Fleinhardt 是Charlie的学院导师，他希望Charlie专注于学术研究而不是浪费无谓的精力帮助警方破案。
NUMB3RS将会通过真实的事例，反映数学理论是如何被应用到警方的调查之中，从而破解一件件匪夷所思的罪案......……